Aim: The research was carried out
to investigate the analgesic and anti-inflammatory effects of ethanol extract of
Desmodium pauciflorum, Mangifera indica and Andrographis paniculata
leaves.
Materials and Methods: In order to assess the analgesic and
anti-inflammatory effects acetic acid induced writhing response model and
carrageenan induced paw edema model were used in Swiss albino mice and Wistar
albino rats, respectively. In both cases, leaves extract were administered
(2gm/kg body weight) and the obtained effects were compared with commercially
available analgesic and anti-inflammatory drug Dclofenac sodium (40mg/kg body
weight). Distilled water (2ml/kg body weight) was used as a control for the
study.
Results: In analgesic bioassay, oral administration of the ethanol
extract of leaves were significantly (p<0.01) reduced the writhing
response. The efficacy of leaves extract were almost 35% in Desmodium
pauciflorum, 56% in Mangifera indica and 34% in Andrographis
paniculata which is found comparable to the effect of standard analgesic
drug diclofenac sodium (76%). Leaves extract reduced paw edema in variable
percentages but they did not show any significant difference among the leaves.
Conclusion: We recommend further research on these plant leaves for
possible isolation and characterization of the various active chemical
substances which has the toxic and medicinal values.
Keywords: acetic
acid, analgesic, anti-inflammatory, carrageenan, diclofenac sodium, medicinal
plant
